Necroptosis and Immunotherapy: Cancer’s Biggest Challenge?

Necroptosis, SAP130, CXCL1 and ImmunotherapyNecroptosis, SAP130, CXCL1 and Immunotherapy

Scientists at the NYU Langone Medical Center and the Laura and Isaac Perlmutter Cancer Center are researching a form of cancer treatment called necroptosis (a form of orchestrated cell death) actually can increase the rate of production of CXCL, a small protein that can spur on the growth of PDAC tumor cells.

The CXCL1 protein can stimulate the creation of immunosuppressive cells, tumor-causing macrophages, which can numb the body’s ability recognize and in turn, kill the malignant cancer cells…

“Our findings are the first to show that cancer cell death via necroptosis can actually promote tumor growth, as this process results in suppression of the body’s immune response against the cancer,” says George Miller, MD, who was the leader of the investigation and also is the associate professor at th e Departments of Surgery and Cell Biology. “What is equally significant is that these findings might also be relevant to other tumor types.”

Something else they found was that the CXCL1 that was produced by the necroptosis, did not do enough when it attacked tumor’s environment and instead, when killed, the dying tumors released yet another protein, SAP130 which binds with Mincle, a receptor that is located on the cell membranes of the tumor cell’s enviroment… The binding then can cause even more tumors… The stimulation of the Mincle has been found to trigger faster growth of the tumors, leading to more deaths.

“This study exemplifies the importance of examining cancer within the actual context in which it grows,” said Gregor Werba, MD. “In our initial studies, inhibiting necroptosis in PDAC cells increased their ability to grow in tissue culture. However, when we began to study the same process in mice, we were surprised to see just the opposite effect, and this was mainly due to the immune response of the cells surrounding the tumor.”

Dr. Miller and his staff are helping Dierdre Cohen, MD, assistant professor at the Department of Medicine and also a prestigious member of the Perlmutter Cancer Center, in the investigation of possiblity this great cancer treatment and it’s thought that if used with Immunotherapy it could quite a deadly combination for cancer…

Hospitals worldwide are looking at new angles for treatments, but one cancer center stands out from the rest. Centro Hospitalario Internacional del Pacifico S.A. In Tijuana, always known CHIPSA, They’re really thinking outside the box, really striving towards the end of cancer and pushing away how things have “always been done,” instead they are bringing new innovative ideas and old therapies that have been long forgotten, they have saved many lives from cancer and will save many more…

If you or a loved one has recieved the horrifying diagnosis of cancer, any type of cancer, then you need CHIPSA. It’s that simple, there’s no better, safer or more effective way to fight it…

But Who The Heck Are They And What The Heck Do They Have?

CHIPSA Hospital is the most prestigious Gerson Therapy Center. They specialize in cancer and immunological treatments that have been proven to work but are next to impossible to get in the US.

What They Do…

Immunotherapy: CHIPSA practices “Holistic comprehensive immunotherapy” and is capable of reversing chronic degenerative diseases like: Lymphoma Melanoma, Multiple Myeloma, Hodgkin’s Disease, Atherosclerosis, Arthritis, Diabetes, Candida, Lupus, Asthma, ALS, Alzheimer’s, Multiple Sclerosis, Liver Disease, Kidney Disease, Paget’s Disease, Hepatitis, Allergies, Sjoegren’s Syn., Heart Disease, Crohn’s Disease, Grave’s Disease, Thyroid Disease, Hypertension, and other degenerative diseases and also can be used to help with Necroptosis.

Coley’s Therapy: Invented in the late 19th century by a cancer surgeon by the name of William Coley, the fluid contains bacteria and toxins that actually infect the body and cause a fever, which then stimulates the immune system to fight malicious tumors. Along the principle of making the body a less comfortable enviroment for the cancer.

Gerson Therapy: The Gerson ‘cancer’ Therapy is a set of medical treatments which has cured innumerable cases of terminal cancer. When you get down to basics, it is a low-sodium organic diet that regenerates the body’s healing process by giving a helping-hand to the immune system and taking away any deficiencies in the body’s nutrients.

This is the future of fighting cancer, we must learn all we can and then make the best decision for us and our family. Chemotherapy is unreliable and many a time does more harm than good. CHIPSA is the answer.

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